Pharmacological Screening of Aquoues and Methanolic Extract of Moringa Oleifera for Anti-Inflammatory and Analgesic Activity

Abstract

Using a battery of experimental models, this research compares the anti-inflammatory and analgesic effects of Moringa oleifera leaf extracts. Results from the tail flick test in rats and the acetic acid-induced writhing in mice were used to determine the analgesic efficacy of Moringa oleifera leaves. Rats were tested for their ability to reduce inflammation by inducing paw edoema with carrageenan and by observing the growth of cotton pellet-granulomas in rats. Also assessed were the
results of administering diclofenac, a reference standard. The edoema caused by carrageenan in rats' paws was significantly reduced after treatment with the methanol extract. It was discovered that the latency duration could be increased in the tail flick approach more effectively using methanolic and aqueous extracts. The findings corroborate the traditional therapeutic usage of Moringa oleifera, suggesting that it contains analgesic and anti-inflammatory properties.